Modeling of Biological Structures Training Course

Node ID: 15091
 

Duration

21 hours
 

Requirements

Molecular biology background is essential, including knowledge about biological macromolecules proteins, RNA and DNA.

 

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Overview

This is a practical workshop, which will introduce basics of molecular modelling of proteins, RNA and DNA. It is well suited for people with biological background, with knowledge in molecular biology, who want to learn how to predict 3D structures of proteins, RNA and DNA molecules.

It is especially suitable for:

  • Researches working in experimental laboratories on structure determination or analysis
  • Scientists whose main area of expertise is not biology, but they need to cope with the results of structural biology research
  • Managers introducing new products (e.g. drugs) who want to broaden their knowledge about novel techniques and possibilities in the field of drug design, structural biology and bioinformatics
  • Computer programmers who are going to write programs dealing with biomolecules.

The course is divided into theoretical and practical part. The lecture is interwoven with simple practical exercises, quizzes and tests to make sure attendees understand the concepts.

During the training you will be taught how to use software dedicated for building 3D models. Furthermore, we will show how to improve and assess models.

During the course we will present various software and different approaches used in novel structure modelling techniques. Our aim is to facilitate your understanding of modelling principles, reasoning and structure-based conclusion making process.

By the end of the course you will be able to prepare a 3D structure model of protein, RNA or DNA molecules of reasonable standard.

 

Course Outline

Protein modelling

  • Two main approaches in 3D structure modelling de novo, homology
  • Homology modelling basics background, techniques, software
  • Choosing a template
  • Alignment preparation
  • Preparing a model
  • Model assessment

RNA modelling

  • Types of modelling de novo, homology
  • Homology modelling basics background, techniques, software
  • Choosing a template
  • Alignment preparation
  • Preparing a model
  • Model assessment